Mitochondria–ER hubs

Knowledge Hubs for Health

The evolution of hubs

The evolution of hubs etabolic networks rely heavily on a few crucial metabolic hubs, such as ATP, NADH, and glutamate, that are widely used in many cellular biochemical reactions. In contrast to hubs, most other metabolites each participate in only a few reactions. Now, research from Thomas Pfeiffer, Orkun Soyer, and Sebastian Bonhoeffer (ETH Zürich, Switzerland) shows that hubs are the natura...

Knowledge Hubs for Health

The Hidden Hubs Problem

We introduce the following hidden hubs model H(n, k, σ0, σ1): the input is an n × n random matrix A with a subset S of k special rows (hubs); entries in rows outside S are generated from the Gaussian distribution p0 = N(0, σ 0), while for each row in S, an unknown subset of k of its entries are generated from p1 = N(0, σ 1), σ1 > σ0, and the rest of the entries from p0. The special rows with hi...

Semantic Hubs for Geological Projects

This paper describes a service-oriented architecture for accessing resources through semantically designed portals called hubs. The services are dedicated to: (a) ontology management, (b) annotation generation from texts based on linguistic or machine learning techniques, (c) persistent storage of ontologies and metadata, and (d) semantic search in annotation bases or ontological databases. The...